Osteoarthritis Clinical Studies

1. Hesslink R, et al, Cetylated Fatty Acids Improve Knee Function in Patients with Osteoarthritis, J Rheumatology, 2002; 29:1708-12.

Sixty-four patients with chronic osteoarthritis of the knee participated in a double-blind, placebo-controlled trial.  They were evaluated at baseline, day 30, and day 68 by physician assessment, knee ranges of motion with goniometry, and the Lequesne Algofunctional Index (LAI).

  • After 68 days patients treated with cetylated fatty acids (CFA) exhibited significant (p<0.001) increase in knee flexion (10.1º) compared to the placebo group (1.1º)
  • Patient responses to the LAI indicated a significant (p<0.001) shift towards functional improvement for the treated group (-5.4 points) compared to a modest improvement in the placebo group (-2.1 points)
  • CFA may be an alternative to the use of Nonsteroidal anti-inflammatory drugs for the treatment of OA